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Article

Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction.

Molecular and cellular biology - 1 Apr 1999

Datto M B, Frederick J P, Pan L, Borton A J, Zhuang Y, Wang X F

Abstract excerpt

The Smads are a family of nine related proteins which function as signaling intermediates for the transforming growth factor beta (TGF-beta) superfamily of ligands. To discern the in vivo functions of one of these Smads, Smad3, we generated mice harboring a targeted disruption of this gene. Smad3 null mice, although smaller than wild-type littermates, are viable, survive to adulthood, and exhibit an early...

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Identifiers

PMID: 10082515
DOI: 10.1128/MCB.19.4.2495
PMCID: PMC84042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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