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Article

Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jun 2003

Su Tao, Suzui Masumi, Wang Lei, Lin Chyuan-Sheng, Xing Wang-Qiu, Weinstein I Bernard

Abstract excerpt

PKC-interacting protein (PKCI), also designated histidine triad nucleotide-binding protein 1, belongs to the histidine triad (HIT) family of proteins. Its structure is highly conserved from bacteria to humans and shares homology with the tumor-suppressor gene fragile histidine triad (FHIT). Although it was originally thought to inhibit PKC, its actual physiologic function is not known. Therefore, we used the...

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Source

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Identifiers

PMID: 12810953
DOI: 10.1073/pnas.1332160100
PMCID: PMC164672

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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