Article
Mice with reduced expression of the telomere-associated protein Ft1 develop p53-sensitive progeroid traits.
Aging cell - 1 Aug 2018
La Torre Mattia, Merigliano Chiara, Burla Romina, Mottini Carla, Zanetti Giorgia, Del Giudice Simona, Carcuro Mariateresa, Virdia Ilaria, Bucciarelli Elisabetta, Manni Isabella, Vinciguerra Gianluca Rampioni, Piaggio Giulia, Riminucci Mara, Cumano Ana, Bartolazzi Armando, Vernì Fiammetta, Soddu Silvia, Gatti Maurizio, Saggio Isabella
Abstract excerpt
Human AKTIP and mouse Ft1 are orthologous ubiquitin E2 variant proteins involved in telomere maintenance and DNA replication. AKTIP also interacts with A- and B-type lamins. These features suggest that Ft1 may be implicated in aging regulatory pathways. Here, we show that cells derived from hypomorph Ft1 mutant (Ft1kof/kof ) mice exhibit telomeric defects and that Ft1kof/kof animals develop progeroid traits,...
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