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Article

Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.

The EMBO journal - 15 Nov 2002

Espejel Silvia, Franco Sonia, Sgura Antonella, Gae Darren, Bailey Susan M, Taccioli Guillermo E, Blasco María A

Abstract excerpt

DNA-PKcs is the catalytic subunit of the DNA-dependent protein kinase (DNA-PK) complex that functions in the non-homologous end-joining of double-strand breaks, and it has been shown previously to have a role in telomere capping. In particular, DNA-PKcs deficiency leads to chromosome fusions involving telomeres produced by leading-strand synthesis. Here, by generating mice doubly deficient in DNA-PKcs and...

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Identifiers

PMID: 12426399
DOI: 10.1093/emboj/cdf593
PMCID: PMC137185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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