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Article

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation.

The Journal of experimental medicine - 12 Mar 2012

López-Contreras Andres J, Gutierrez-Martinez Paula, Specks Julia, Rodrigo-Perez Sara, Fernandez-Capetillo Oscar

Abstract excerpt

Replicative stress (RS) is a type of endogenous DNA damage that cells suffer every time they duplicate their genomes, and which is further boosted by oncogenes. In mammals, the RS response (RSR) is coordinated by ATR and Chk1 kinases. We sought to develop a mammalian organism that is selectively protected from RS. To this end, mice carrying an extra copy of the Chk1 gene were generated. In vitro, Chk1 transgenic...

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Identifiers

PMID: 22370720
DOI: 10.1084/jem.20112147
PMCID: PMC3302228

Genes

ATR
ATM

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