Article
The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients.
Clinical endocrinology - 1 Jul 2003
Di Blasio Anna Maria, van Rossum Elisabeth F C, Maestrini Sabrina, Berselli Maria Elisa, Tagliaferri Mariantonella, Podestà Francesca, Koper Jan W, Liuzzi Antonio, Lamberts Steven W J
Abstract excerpt
OBJECTIVE: We have recently reported that, in healthy elderly Dutch individuals, a N363S polymorphism in the glucocorticoid receptor (GR) gene is associated with higher sensitivity to low-dose dexamethasone (0.25 mg), evaluated as both cortisol suppression and insulin response, and with an increased body mass index (BMI). In the present study we investigated the role of the N363S polymorphism, and a BclI...
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