Article
Prevalence and cardiometabolic associations of the glucocorticoid receptor gene polymorphisms N363S and BclI in obese and non-obese black and white Mississippians.
Hormones (Athens, Greece) - 1 Jan 2000
Melcescu Eugen, Griswold Michael, Xiang Lianbin, Belk Sheila, Montgomery Denise, Bray Marilyn, Del Ben Kevin S, Uwaifo Gabriel I, Marshall Gailen D, Koch Christian A
Abstract excerpt
OBJECTIVE: Polymorphisms (SNP) in the glucocorticoid receptor (GR) gene can alter sensitivity to glucocorticoids. Previous studies of the N363S and BclI SNP in the GR gene have shown a metabolic syndrome phenotype in mostly non-African populations. The obesity phenotype of African Americans (AA) seems to be more severe than that of Caucasians. DESIGN: We aimed to assess the prevalence of N363S and BclI in obese...
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