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Article

An association between a Bc1I restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women.

Journal of molecular endocrinology - 1 Dec 1992

Weaver J U, Hitman G A, Kopelman P G

Abstract excerpt

Obesity is likely to be a multifactorial disease with an important genetic component. Animal models of genetic and experimentally induced obesity suggest that glucocorticoid receptor (GR) activity plays a role in the aetiology and maintenance of the obese state. Glucocorticoid activity appears to be essential for the development of hyperinsulinaemia and subsequent fat deposition. In humans, glucocorticoid excess...

Topics

Adult
Alleles
Female
Gene Frequency
Genotype
Humans
Hyperinsulinism
Insulin
Insulin Resistance
Insulin Secretion
Obesity
Polymorphism, Restriction Fragment Length

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Glucocorticoid

Source

Identifiers

PMID: 1362060
DOI: 10.1677/jme.0.0090295

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1362060-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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