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Article

Meta-analysis on the effect of the N363S polymorphism of the glucocorticoid receptor gene (GRL) on human obesity.

BMC medical genetics - 25 May 2006

Marti Amelia, Ochoa M Carmen, Sánchez-Villegas Almudena, Martínez J Alfredo, Martínez-González Miguel Angel, Hebebrand Johannes, Hinney Anke, Vedder Helmut

Abstract excerpt

BACKGROUND: Since both excess glucocorticoid secretion and central obesity are clinical features of some obese patients, it is worthwhile to study a possible association of glucocorticoid receptor gene (GRL) variants with obesity. Previous studies have linked the N363S variant of the GRL gene to increased glucocorticoid effects such as higher body fat, a lower lean-body mass and a larger insulin response to...

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Identifiers

PMID: 16725041
DOI: 10.1186/1471-2350-7-50
PMCID: PMC1481544

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