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Article

Mice lacking phosphatidylinositol transfer protein-alpha exhibit spinocerebellar degeneration, intestinal and hepatic steatosis, and hypoglycemia.

The Journal of biological chemistry - 29 Aug 2003

Alb James G, Cortese Jorge D, Phillips Scott E, Albin Roger L, Nagy Tim R, Hamilton Bruce A, Bankaitis Vytas A

Abstract excerpt

Phosphatidylinositol transfer proteins (PITPs) regulate the interface between lipid metabolism and cellular functions. We now report that ablation of PITP alpha function leads to aponecrotic spinocerebellar disease, hypoglycemia, and intestinal and hepatic steatosis in mice. The data indicate that hypoglycemia is in part associated with reduced proglucagon gene expression and glycogenolysis that result from...

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Identifiers

PMID: 12788952
DOI: 10.1074/jbc.M303591200
PMCID: PMC7798478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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