Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice.

American journal of physiology. Endocrinology and metabolism - 1 Jul 2024

Zhou Hongyi, Fick Kendra, Patel Vijay, Hilton Lisa Renee, Kim Ha Won, Bagi Zsolt, Weintraub Neal L, Chen Weiqin

Abstract excerpt

Acylglycerophosphate acyltransferases (AGPATs) catalyze the de novo formation of phosphatidic acid to synthesize glycerophospholipids and triglycerides. AGPATs demonstrate unique physiological roles despite a similar biochemical function. AGPAT3 is highly expressed in the testis, kidney, and liver, with intermediate expression in adipose tissue. Loss of AGPAT3 is associated with reproductive abnormalities and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 1-Acylglycerol-3-Phosphate O-Acyltransferase
Share to Acyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adipocytes

Share to Adipogenesis

Share to Adipose Tissue, Brown

Share to Energy Metabolism

Share to Thermogenesis

Share to Thinness

Source

Open in PubMed Open full text

Identifiers

PMID: 38717361
DOI: 10.1152/ajpendo.00012.2024
PMCID: PMC11390115

Genes

AGPAT3
AGPAT2
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

AGPAT3 deficiency impairs adipocyte differentiation and leads to a lean phenotype in mice.PMID 38717361Read ↗

Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseasesSemantic proximity Read ↗

A regulatory role for 1-acylglycerol-3-phosphate-O-acyltransferase 2 in adipocyte differentiation.Semantic proximity Read ↗

Loss of adipocyte phospholipase gene <i>PLAAT3</i> causes lipodystrophy and insulin resistance due to inactivated arachidonic acid-mediated PPAR <i>γ</i> signalingSemantic proximity Read ↗

Adiposity and metabolic health in mice deficient in intestinal alkaline phosphatase.Semantic proximity Read ↗

Oligomers of the lipodystrophy protein seipin may co-ordinate GPAT3 and AGPAT2 enzymes to facilitate adipocyte differentiation.Semantic proximity Read ↗

Thematic Review Series: Glycerolipids. Multiple roles for lipins/phosphatidate phosphatase enzymes in lipid metabolism.Semantic proximity Read ↗

Substrate-Specific Function of PNPLA3 Facilitates Hepatic VLDL-Triglyceride Secretion During Stimulated LipogenesisSemantic proximity Read ↗

Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.Semantic proximity Read ↗

Agpat6—a novel lipid biosynthetic gene required for triacylglycerol production in mammary epitheliumSemantic proximity Read ↗

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndromeSemantic proximity Read ↗

<i>Keratinocyte-Associated Protein 3</i> is a novel gene for adiposity with differential effects in males and femalesSemantic proximity Read ↗

Monoacylglycerol O-acyltransferase 1 is required for adipocyte differentiation <i>in vitro</i> but does not affect adiposity in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.