Article

p110α-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLD

2024-01-10

Abstract excerpt

Insulin and other growth factors are key regulators of liver gene expression, including in metabolic diseases. Most of the phosphoinositide 3-kinase (PI3K) activity induced by insulin is dependent on PI3Kα. We used mice lacking p110α, the catalytic subunit of PI3Kα, to investigate its role in the regulation of liver gene expression in health and in Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD)....

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Literature Corpus work: 53aa9c1d-4864-58f3-8bf4-72f334e2526b
DOI: 10.1101/2024.01.09.574858

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