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Article

The pathologies associated with functional titration of phosphatidylinositol transfer protein alpha activity in mice.

Journal of lipid research - 1 Aug 2007

Alb James G, Phillips Scott E, Wilfley Lindsey R, Philpot Benjamin D, Bankaitis Vytas A

Abstract excerpt

Phosphatidylinositol transfer proteins (PITPs) bind phosphatidylinositol (PtdIns) and phosphatidylcholine and play diverse roles in coordinating lipid metabolism/signaling with intracellular functions. The underlying mechanisms remain unclear. Genetic ablation of PITPalpha in mice results in neonatal lethality characterized by intestinal and hepatic steatosis, spinocerebellar neurodegeneration, and glucose...

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Identifiers

PMID: 17525475
DOI: 10.1194/jlr.M700145-JLR200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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