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Article

Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice.

Journal of molecular and cellular cardiology - 1 Jun 2003

Barouch Lili A, Cappola Thomas P, Harrison Robert W, Crone Julie K, Rodriguez E Rene, Burnett Arthur L, Hare Joshua M

Abstract excerpt

Deficiency of either neuronal nitric oxide synthase (NOS1) or endothelial nitric oxide synthase (NOS3) leads to cardiac hypertrophy in mice. Loss of both produces concentric left ventricular (LV) remodeling, in which increased wall thickness is accompanied by reduced cavity size. In humans, this phenotype develops in elderly hypertensive patients and independently predicts mortality. Accordingly, we tested the...

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Source

Identifiers

PMID: 12788381
DOI: 10.1016/s0022-2828(03)00079-8

Genes

NOS1
NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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