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Article

Fetal origins of adult vascular dysfunction in mice lacking endothelial nitric oxide synthase

31 Dec 2004

Abstract excerpt

Epidemiological studies have shown increased incidence of hypertension and coronary artery disease in growth-restricted fetuses during their adult life. A novel animal model was used to test the hypothesis regarding the role of an abnormal uterine environment in fetal programming of adult vascular dysfunction. Mice lacking a functional endothelial nitric oxide synthase (NOS3-/-KO, where KO is knockout) and...

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PMID: 15626780
DOI: 10.1152/ajpregu.00367.2004

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