Article
Disturbed nitric oxide signalling gives rise to congenital bicuspid aortic valve and aortopathy.
Disease models & mechanisms - 28 Sept 2020
Peterson Joshua C, Wisse Lambertus J, Wirokromo Valerie, van Herwaarden Tessa, Smits Anke M, Gittenberger-de Groot Adriana C, Goumans Marie-José T H, VanMunsteren J Conny, Jongbloed Monique R M, DeRuiter Marco C
Abstract excerpt
Patients with a congenital bicuspid aortic valve (BAV), a valve with two instead of three aortic leaflets, have an increased risk of developing thoracic aneurysms and aortic dissection. The mechanisms underlying BAV-associated aortopathy are poorly understood. This study examined BAV-associated aortopathy in Nos3-/- mice, a model with congenital BAV formation. A combination of histological examination and in vivo...
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