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Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background

9 Mar 2015

Abstract excerpt

Thoracic aortic aneurysms (TAA) are a significant cause of morbidity and mortality in humans. While the exact etiology is unknown, genetic factors play an important role. Mutations in NOTCH1 have been linked to bicuspid aortic valve (BAV) and aortopathy in humans. The aim of this study was to determine if haploinsufficiency of Notch1 contributes to aortopathy using Notch1+/−; Nos3−/− mice. Echocardiographic...

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PMID: 25914885
DOI: 10.3390/jcdd2010017

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