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Article

Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases.

Circulation research - 27 Jun 2003

Khan Shakil A, Skaf Michel W, Harrison Robert W, Lee Kwangho, Minhas Khalid M, Kumar Anil, Fradley Mike, Shoukas Artin A, Berkowitz Dan E, Hare Joshua M

Abstract excerpt

The mechanisms by which nitric oxide (NO) influences myocardial Ca2+ cycling remain controversial. Because NO synthases (NOS) have specific spatial localization in cardiac myocytes, we hypothesized that neuronal NOS (NOS1) found in cardiac sarcoplasmic reticulum (SR) preferentially regulates SR Ca2+ release and reuptake resulting in potentiation of the cardiac force-frequency response (FFR). Transesophageal...

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Source

Identifiers

PMID: 12764022
DOI: 10.1161/01.RES.0000078171.52542.9E

Genes

NOS1
NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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