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Article

In vitro GAP activity towards RhoA, Rac1 and Cdc42 is not a prerequisite for YopE induced HeLa cell cytotoxicity.

Microbial pathogenesis - 1 Jun 2003

Aili Margareta, Telepnev Maxim, Hallberg Bengt, Wolf-Watz Hans, Rosqvist Roland

Abstract excerpt

The YopE cytotoxin of Yersinia is an essential virulence determinant that is translocated into the eukaryotic target cell via a plasmid-encoded type III secretion system. YopE possess a GTPase activating protein activity that in vitro has been shown to down regulate RhoA, Rac1, and Cdc42. Translocated YopE induces de-polymerisation of the actin microfilament structure in the eukaryotic cell which results in a...

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Identifiers

PMID: 12782482
DOI: 10.1016/s0882-4010(03)00063-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In vitro GAP activity towards RhoA, Rac1 and Cdc42 is not a prerequisite for YopE induced HeLa cell cytotoxicity.PMID 12782482Read ↗

Functional analysis of the YopE GTPase-activating protein (GAP) activity of Yersinia pseudotuberculosis.Semantic proximity Read ↗

The cytotoxic protein YopE of Yersinia obstructs the primary host defence.Semantic proximity Read ↗

The chaperone-like protein YerA of Yersinia pseudotuberculosis stabilizes YopE in the cytoplasm but is dispensible for targeting to the secretion loci.Semantic proximity Read ↗

YopK of Yersinia pseudotuberculosis controls translocation of Yop effectors across the eukaryotic cell membrane.Semantic proximity Read ↗

The cytotoxin YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding protein RhoA.Semantic proximity Read ↗

YerA mediates the secretion of the YopE cytotoxin of Yersinia pseudotuberculosis.Semantic proximity Read ↗

Yersinia YopE is targeted for type III secretion by N-terminal, not mRNA, signals.Semantic proximity Read ↗

Yersinia enterocolitica can deliver Yop proteins into a wide range of cell types: development of a delivery system for heterologous proteins.Semantic proximity Read ↗

Regulation of Yersinia Yop-effector delivery by translocated YopE.Semantic proximity Read ↗

Destabilization of YopE by the ubiquitin-proteasome pathway fine-tunes Yop delivery into host cells and facilitates systemic spread of Yersinia enterocolitica in host lymphoid tissue.Semantic proximity Read ↗

Reduced secretion of YopJ by Yersinia limits in vivo cell death but enhances bacterial virulence.Semantic proximity Read ↗

The Yersinia YpkA Ser/Thr kinase is translocated and subsequently targeted to the inner surface of the HeLa cell plasma membrane.Semantic proximity Read ↗

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