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Article

Functional analysis of the YopE GTPase-activating protein (GAP) activity of Yersinia pseudotuberculosis.

Cellular microbiology - 1 Jun 2006

Aili Margareta, Isaksson Elin L, Hallberg Bengt, Wolf-Watz Hans, Rosqvist Roland

Abstract excerpt

YopE of Yersinia pseudotuberculosis inactivates three members of the small RhoGTPase family (RhoA, Rac1 and Cdc42) in vitro and mutation of a critical arginine abolishes both in vitro GTPase-activating protein (GAP) activity and cytotoxicity towards HeLa cells, and renders the pathogen avirulent in a mouse model. To understand the functional role of YopE, in vivo studies of the GAP activity in infected eukaryotic...

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PMID: 16681842
DOI: 10.1111/j.1462-5822.2005.00684.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Functional analysis of the YopE GTPase-activating protein (GAP) activity of Yersinia pseudotuberculosis.PMID 16681842Read ↗

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