Article
Destabilization of YopE by the ubiquitin-proteasome pathway fine-tunes Yop delivery into host cells and facilitates systemic spread of Yersinia enterocolitica in host lymphoid tissue.
Infection and immunity - 1 Mar 2011
Gaus Kristin, Hentschke Moritz, Czymmeck Nicole, Novikova Lena, Trülzsch Konrad, Valentin-Weigand Peter, Aepfelbacher Martin, Ruckdeschel Klaus
Abstract excerpt
Pathogenic Yersinia species inject a panel of Yop virulence proteins by type III protein secretion into host cells to modulate cellular defense responses. This enables the survival and dissemination of the bacteria in the host lymphoid tissue. We have previously shown that YopE of the Y. enterocolitica serogroup O8 is degraded in the host cell through the ubiquitin-proteasome pathway. YopE normally manipulates...
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