Article
The cytotoxin YopT of Yersinia enterocolitica induces modification and cellular redistribution of the small GTP-binding protein RhoA.
The Journal of biological chemistry - 8 Oct 1999
Zumbihl R, Aepfelbacher M, Andor A, Jacobi C A, Ruckdeschel K, Rouot B, Heesemann J
Abstract excerpt
Pathogenic Yersinia enterocolitica produces two virulence plasmid-encoded cytotoxins, YopE and YopT, that are translocated into target cells where they disrupt the actin cytoskeleton. Here we show that infection of cells with wild type Y. enterocolitica and a yopE mutant, but not with a yopT mutant, induces an increase in the electrophoretic mobility of the small GTPase RhoA. As tested by isoelectric focusing,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.