Article
Yersinia enterocolitica can deliver Yop proteins into a wide range of cell types: development of a delivery system for heterologous proteins.
European journal of cell biology - 1 Oct 2000
Boyd A P, Grosdent N, Tötemeyer S, Geuijen C, Bleves S, Iriarte M, Lambermont I, Octave J N, Cornelis G R
Abstract excerpt
Y. enterocolitica translocates virulence proteins, called Yop effectors, into the cytosol of eukaryotic cells. Here we investigated whether Y. enterocolitica could translocate Yops into a range of eukaryotic cells including neurons and insect cells. Y. enterocolitica translocated the hybrid reporter protein YopE-Cya into each of the eukaryotic cell types tested. In addition, Y. enterocolitica was cytotoxic for...
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