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Article

Regulation of Yersinia Yop-effector delivery by translocated YopE.

International journal of medical microbiology : IJMM - 1 Apr 2008

Aili Margareta, Isaksson Elin L, Carlsson Sara E, Wolf-Watz Hans, Rosqvist Roland, Francis Matthew S

Abstract excerpt

The bacterial pathogen Yersinia pseudotuberculosis uses a type III secretion (T3S) system to translocate Yop effectors into eukaryotic cells. Effectors are thought to gain access to the cytosol via pores formed in the host cell plasma membrane. Translocated YopE can modulate this pore formation through its GTPase-activating protein (GAP) activity. In this study, we analysed the role of translocated YopE and all...

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Identifiers

PMID: 17597003
DOI: 10.1016/j.ijmm.2007.04.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of Yersinia Yop-effector delivery by translocated YopE.PMID 17597003Read ↗

YopK of Yersinia pseudotuberculosis controls translocation of Yop effectors across the eukaryotic cell membrane.Semantic proximity Read ↗

TyeA of Yersinia pseudotuberculosis is involved in regulation of Yop expression and is required for polarized translocation of Yop effectors.Semantic proximity Read ↗

The Yersinia YpkA Ser/Thr kinase is translocated and subsequently targeted to the inner surface of the HeLa cell plasma membrane.Semantic proximity Read ↗

Yersinia enterocolitica can deliver Yop proteins into a wide range of cell types: development of a delivery system for heterologous proteins.Semantic proximity Read ↗

Yersinia YopE is targeted for type III secretion by N-terminal, not mRNA, signals.Semantic proximity Read ↗

Translocation of surface-localized effectors in type III secretion.Semantic proximity Read ↗

The chaperone-like protein YerA of Yersinia pseudotuberculosis stabilizes YopE in the cytoplasm but is dispensible for targeting to the secretion loci.Semantic proximity Read ↗

Yersinia pseudotuberculosis YopD mutants that genetically separate effector protein translocation from host membrane disruption.Semantic proximity Read ↗

Evidence for targeting of Yop effectors by the chromosomally encoded Ysa type III secretion system of Yersinia enterocolitica.Semantic proximity Read ↗

Destabilization of YopE by the ubiquitin-proteasome pathway fine-tunes Yop delivery into host cells and facilitates systemic spread of Yersinia enterocolitica in host lymphoid tissue.Semantic proximity Read ↗

Functional analysis of the YopE GTPase-activating protein (GAP) activity of Yersinia pseudotuberculosis.Semantic proximity Read ↗

Status of YopM and YopN in the Yersinia Yop virulon: YopM of Y.enterocolitica is internalized inside the cytosol of PU5-1.8 macrophages by the YopB, D, N delivery apparatus.Semantic proximity Read ↗

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