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Article

Mapping of a candidate colorectal cancer tumor-suppressor gene to a 900-kilobase region on the short arm of chromosome 8.

Genes, chromosomes & cancer - 1 Jul 2004

Flanagan James M, Healey Sue, Young Joanne, Whitehall Vicki, Trott Deborah A, Newbold Robert F, Chenevix-Trench Georgia

Abstract excerpt

Loss of heterozygosity (LOH) on 8p occurs at high frequencies in many tumor types, including colorectal carcinoma (CRC). We previously used microcell-mediated chromosome transfer (MMCT) into the CRC cell line SW620 to map a approximately 7.7-Mb colorectal cancer-suppressor region (CRCSR) at 8p22-23.1. In the current study, we transferred small fragments of this CRCSR into SW620 to refine the region further. Two...

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PMID: 15139003
DOI: 10.1002/gcc.20039

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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