Article
Evolution of 8p loss in transformed human prostate epithelial cells.
Cancer genetics and cytogenetics - 1 Oct 2004
Macoska Jill A, Paris Pamela, Collins Colin, Andaya Armann, Beheshti Ben, Chaib Hassan, Kant Rajiv, Begley Lesa, MacDonald James W, Squire Jeremy A
Abstract excerpt
Deletion or rearrangement of sequences that map to the short arm of chromosome 8 (8p) are frequently associated with human prostate tumorigenesis. These losses often involve the entire short arm of chromosome 8 or very large regions of distal or proximal 8p, and several putative tumor suppressor genes mapping to 8p have been described. However, the mechanism responsible for 8p loss during prostate tumorigenesis...
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