Article
A human cancer-associated truncation of MBD4 causes dominant negative impairment of DNA repair in colon cancer cells.
British journal of cancer - 26 Feb 2007
Bader S A, Walker M, Harrison D J
Abstract excerpt
MBD4 binds to methylated DNA and acts as a thymine DNA glycosylase in base excision repair. Deficiency of MBD4 in mice enhances mutation at CpG sites and alters apoptosis in response to DNA damage, but does not increase tumorigenesis in mismatch repair-deficient mice. However, in humans, frameshift mutation of MBD4, rather than deletion, is what occurs in up to 43% of microsatellite unstable colon cancers. There...
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