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Article

Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers

3 Mar 2005

Abstract excerpt

Genome-wide screening of DNA copy number aberrations in 27 cell lines derived from non-small cell lung cancers (NSCLCs), using a custom-made comparative genomic hybridization (CGH)-array, identified a homozygous deletion of the deleted in bladder cancer 1 gene (DBC1) in one cell line. Homozygous deletion of DBC1, located at 9q33.1, was also observed in two of 53 primary NSCLC tumors examined. Moreover, 21 of the...

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PMID: 15746151
DOI: 10.1093/hmg/ddi092

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