Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Runx3 knockouts and stomach cancer.

EMBO reports - 1 Jun 2003

Levanon Ditsa, Brenner Ori, Otto Florian, Groner Yoram

Abstract excerpt

Gene targeting often results in knockout mice that show several phenotypes, some of which may not directly relate to the intrinsic function of the disrupted gene. Hence, to study the biological function of genes using knockout mice, one must identify the defects that are directly due to the loss of the targeted gene. Runx3 is a transcription factor that regulates lineage-specific gene expression in developmental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Lineage
Share to Core Binding Factor Alpha 3 Subunit
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Promoter Regions, Genetic

Share to Protein Structure, Tertiary

Share to Stomach Neoplasms

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 12776174
DOI: 10.1038/sj.embor.embor868
PMCID: PMC1319207

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Runx3 knockouts and stomach cancer.PMID 12776174Read ↗

Runx3-deficient mouse strains circa 2008: resemblance and dissimilarity.Semantic proximity Read ↗

Loss of Runx3 is a key event in inducing precancerous state of the stomach.Semantic proximity Read ↗

TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes.Semantic proximity Read ↗

Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2.Semantic proximity Read ↗

Molecular pathology of RUNX3 in human carcinogenesis.Semantic proximity Read ↗

RUNX3 in Stem Cell and Cancer Biology.Semantic proximity Read ↗

Generation and Characterization of <i>dickkopf3</i> Mutant MiceSemantic proximity Read ↗

RUNX3 in oncogenic and anti‐oncogenic signaling in gastrointestinal cancersSemantic proximity Read ↗

Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal developmentSemantic proximity Read ↗

Murine models for the study of thyroid gland development.Semantic proximity Read ↗

Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene.Semantic proximity Read ↗

Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.