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Article

Loss of Runx3 is a key event in inducing precancerous state of the stomach.

Gastroenterology - 1 May 2011

Ito Kosei, Chuang Linda Shyue Huey, Ito Tomoko, Chang Ti Ling, Fukamachi Hiroshi, Salto-Tellez Manuel, Ito Yoshiaki

Abstract excerpt

BACKGROUND & AIMS: RUNX3 is a tumor suppressor originally identified in gastric cancer. The mutation R122C in RUNX3 promotes gastric carcinogenesis by unclear mechanisms. We investigated how Runx3-deficiency contributes to distinct changes in the gastric epithelium that precede neoplasia. METHODS: Runx3-deficient (Runx3(-/-)) and wild-type BALB/c adult mice were subjected to histological analyses. Gastric cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21277301
DOI: 10.1053/j.gastro.2011.01.043

Genes

RUNX3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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