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Article

Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development

26 Jul 2011

Abstract excerpt

Goblet cell metaplasia and mucus overproduction contribute to the pathogenesis of chronic lung diseases, including asthma and chronic obstructive pulmonary disease (COPD). Notch signaling regulates cell fate decisions and is crucial in controlling goblet cell differentiation in the gut epithelium. Little is known, however, about how endogenous Notch signaling influences the goblet cell differentiation program...

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PMID: 21791528
DOI: 10.1242/dev.063727

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