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Article

Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.

Development (Cambridge, England) - 1 Oct 2014

Chojnowski Jena L, Masuda Kyoko, Trau Heidi A, Thomas Kirk, Capecchi Mario, Manley Nancy R

Abstract excerpt

Hoxa3 was the first Hox gene to be mutated by gene targeting in mice and is required for the development of multiple endoderm and neural crest cell (NCC)-derived structures in the pharyngeal region. Previous studies have shown that the Hoxa3 null mutant lacks third pharyngeal pouch derivatives, the thymus and parathyroids by E18.5, and organ-specific markers are absent or downregulated during initial...

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Source

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Identifiers

PMID: 25249461
DOI: 10.1242/dev.110833
PMCID: PMC4197593

Genes

HOXA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.PMID 25249461Read ↗

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