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Article

RUNX3 in oncogenic and anti‐oncogenic signaling in gastrointestinal cancers

14 Feb 2011

Abstract excerpt

The reputation of RUNX3 as a strong candidate for a tumor suppressor originated from studies of gastric carcinogenesis and now extends to a variety of other human cancers. The RUNX3 transcription factor is a downstream effector of the TGF-β superfamily signaling pathway and has a critical role in the regulation of cell proliferation, cell death by apoptosis, and cell adhesion. Recently, RUNX3 was proposed as a...

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Share to Genetic factors in colorectal cancer
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PMID: 21465522
DOI: 10.1002/jcb.23047

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