Article
Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene.
Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2001
Xian J, Clark K J, Fordham R, Pannell R, Rabbitts T H, Rabbitts P H
Abstract excerpt
Chromosome 3 allele loss in preinvasive bronchial abnormalities and carcinogen-exposed, histologically normal bronchial epithelium indicates that it is an early, possibly the first, somatic genetic change in lung tumor development. Candidate tumor suppressor genes have been isolated from within distinct 3p regions implicated by heterozygous and homozygous allele loss. We have proposed that DUTT1, nested within...
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