Article
Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2.
The Journal of clinical investigation - 1 Jun 2010
Grigorieva Irina V, Mirczuk Samantha, Gaynor Katherine U, Nesbit M Andrew, Grigorieva Elena F, Wei Qiaozhi, Ali Asif, Fairclough Rebecca J, Stacey Joanna M, Stechman Michael J, Mihai Radu, Kurek Dorota, Fraser William D, Hough Tertius, Condie Brian G, Manley Nancy, Grosveld Frank, Thakker Rajesh V
Abstract excerpt
Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia. Here, we have investigated the role of GATA3 in parathyroid function by challenging Gata3+/- mice with a diet low in calcium and vitamin D so as to expose any defects in parathyroid function. This led to a higher mortality among Gata3+/- mice compared...
Topics
- Animals
- Cell Differentiation
- Genes
- Hepatocyte Nuclear Factor 1-beta
- Hypoparathyroidism
- Mice
- Mice, Knockout
- Mutation
- Neuroglia