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Article

Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells.

The Journal of biological chemistry - 15 Aug 2003

Niedernhofer Laura J, Daniels J Scott, Rouzer Carol A, Greene Rachel E, Marnett Lawrence J

Abstract excerpt

Malondialdehyde (MDA) is an endogenous genotoxic product of enzymatic and oxygen radical-induced lipid peroxidation whose adducts are known to exist in DNA isolated from healthy human beings. To evaluate the mutagenic potential of MDA in human cells, we reacted MDA with pSP189 shuttle vector DNA and then transfected them into human fibroblasts for replication. MDA induced up to a 15-fold increase in mutation...

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PMID: 12775726
DOI: 10.1074/jbc.M212549200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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