Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA damage and mutations produced by chloroacetaldehyde in a CpG-methylated target gene.

Mutation research - 21 Dec 2004

Choi Jun-Hyuk, Pfeifer Gerd P

Abstract excerpt

Chloroacetaldehyde (CAA) is a metabolite of the human carcinogen vinyl chloride. CAA produces several types of DNA adducts including the exocyclic base adducts 3,N(4)-ethenocytosine, 1,N(6)-ethenoadenine, N(2),3-ethenoguanine, and 1,N(2)-ethenoguanine. Adducts of CAA with 5-methylcytosine have not yet been characterized. Here we have analyzed the mutational spectra produced by CAA in the supF gene of the pSP189...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetaldehyde
Share to CpG Islands
Share to DNA Adducts

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Damage

Share to Genes, Suppressor

Share to Genetic Vectors

Share to RNA, Transfer

Share to Taq Polymerase

Source

Identifiers

PMID: 15542111
DOI: 10.1016/j.mrfmmm.2004.09.004

Genes

TDG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA damage and mutations produced by chloroacetaldehyde in a CpG-methylated target gene.PMID 15542111Read ↗

Mechanisms of mutagenesis by the vinyl chloride metabolite chloroacetaldehyde. Effect of gene-targeted in vitro adduction of M13 DNA on DNA template activity in vivo and in vitro.Semantic proximity Read ↗

Genotoxicity and mutagenicity of the alpha, beta-unsaturated carbonyl compound crotonaldehyde (butenal) on a plasmid shuttle vector.Semantic proximity Read ↗

Sequence specificity of aflatoxin B1-induced mutations in a plasmid replicated in xeroderma pigmentosum and DNA repair proficient human cells.Semantic proximity Read ↗

Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells.Semantic proximity Read ↗

Deamination of 5-Methylcytosines within Cyclobutane Pyrimidine Dimers Is an Important Component of UVB MutagenesisSemantic proximity Read ↗

Mutational spectra for polycyclic aromatic hydrocarbons in the supF target gene.Semantic proximity Read ↗

Mutagenicity of vinyl chloride and its reactive metabolites, chloroethylene oxide and chloroacetaldehyde, in a metabolically competent human B-lymphoblastoid line.Semantic proximity Read ↗

Mutagenic specificity of N-acetoxy-3-aminobenzanthrone, a major metabolically activated form of 3-nitrobenzanthrone, in shuttle vector plasmids propagated in human cells.Semantic proximity Read ↗

Mutations at G:C base pairs predominate after replication of peroxyl radical-damaged pSP189 plasmids in human cells.Semantic proximity Read ↗

DNA damage: chemistry, repair, and mutagenic potential.Semantic proximity Read ↗

Spontaneous mutation spectra in supF: comparative analysis of mammalian cell line base substitution spectra.Semantic proximity Read ↗

Copper-dependent site-specific mutagenesis by benzoyl peroxide in the supF gene of the mutation reporter plasmid pS189.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.