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Mutagenic effects of 8-hydroxy-dGTP in live mammalian cells.

Free radical biology & medicine - 15 May 2007

Satou Kazuya, Kawai Kazuaki, Kasai Hiroshi, Harashima Hideyoshi, Kamiya Hiroyuki

Abstract excerpt

The mutagenicity of an oxidized form of dGTP, 8-hydroxy-2'-deoxyguanosine 5'-triphosphate (8-OH-dGTP), was examined using COS-7 cells. 8-OH-dGTP and supF shuttle plasmid DNA were cointroduced by means of cationic liposomes, and the DNAs replicated in the cells were recovered and then transfected into Escherichia coli. 8-OH-dGTP induced A:T-->C:G substitution mutations in the COS-7 cells. This result agrees with...

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PMID: 17448902
DOI: 10.1016/j.freeradbiomed.2007.02.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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