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Mutagenic Potentials of DNA Interstrand Cross-Links Induced by 7,8-Dihydro-8-Oxoadenine.

Molecules (Basel, Switzerland) - 14 Jan 2026

Schmaltz Lillian F, Rodriguez Nestor, Lee Seongmin

Abstract excerpt

DNA interstrand cross-links (ICLs) are among the most cytotoxic forms of DNA damage, arising when the two strands of the DNA helix are covalently linked by crosslink-inducing agents such as bifunctional alkylating agents and reactive aldehydes. Several studies have demonstrated that ICLs can also be induced by reactive oxygen and nitrogen species. We previously reported that under oxidative conditions, the major...

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PMID: 41599340
DOI: 10.3390/molecules31020291
PMCID: PMC12843755

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