Article
Identification of a polymorphic gene, BCL2A1, encoding two novel hematopoietic lineage-specific minor histocompatibility antigens.
The Journal of experimental medicine - 2 Jun 2003
Akatsuka Yoshiki, Nishida Tetsuya, Kondo Eisei, Miyazaki Mikinori, Taji Hirohumi, Iida Hiroatsu, Tsujimura Kunio, Yazaki Makoto, Naoe Tomoki, Morishima Yasuo, Kodera Yoshihisa, Kuzushima Kiyotaka, Takahashi Toshitada
Abstract excerpt
We report the identification of two novel minor histocompatibility antigens (mHAgs), encoded by two separate single nucleotide polymorphisms on a single gene, BCL2A1, and restricted by human histocompatibility leukocyte antigen (HLA)-A*2402 (the most common HLA-A allele in Japanese) and B*4403, respectively. Two cytotoxic T lymphocyte (CTL) clones specific for these mHAgs were first isolated from two distinct...
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