Article
Identification of 4 novel HLA-B*40:01 restricted minor histocompatibility antigens and their potential as targets for graft-versus-leukemia reactivity.
Haematologica - 1 Aug 2012
Griffioen Marieke, Honders M Willy, van der Meijden Edith D, van Luxemburg-Heijs Simone A P, Lurvink Ellie G A, Kester Michel G D, van Bergen Cornelis A M, Falkenburg J H Frederik
Abstract excerpt
BACKGROUND: Patients with hematologic malignancies can be successfully treated with donor lymphocyte infusion after HLA-matched allogeneic hematopoietic stem cell transplantation. The effect of donor lymphocyte infusion is mediated by donor T cells recognizing minor histocompatibility antigens. T cells recognizing hematopoietic restricted minor histocompatibility antigens may induce selective...
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