Article
Identification of human minor histocompatibility antigens based on genetic association with highly parallel genotyping of pooled DNA.
Blood - 15 Mar 2008
Kawase Takakazu, Nannya Yasuhito, Torikai Hiroki, Yamamoto Go, Onizuka Makoto, Morishima Satoko, Tsujimura Kunio, Miyamura Koichi, Kodera Yoshihisa, Morishima Yasuo, Takahashi Toshitada, Kuzushima Kiyotaka, Ogawa Seishi, Akatsuka Yoshiki
Abstract excerpt
Minor histocompatibility (H) antigens are the molecular targets of allo-immunity responsible both for the development of antitumor effects and for graft-versus-host disease (GVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, despite their potential clinical use, our knowledge of human minor H antigens is largely limited by the lack of efficient methods of their characterization....
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