Article
Fine-mapping of HLA associations with chronic lymphocytic leukemia in US populations.
Blood - 23 Oct 2014
Gragert Loren, Fingerson Stephanie, Albrecht Mark, Maiers Martin, Kalaycio Matt, Hill Brian T
Abstract excerpt
Chronic lymphocytic leukemia (CLL) displays remarkable ethnic predisposition for whites, with relative sparing of African-American and Asian populations. In addition, CLL displays among the highest familial predispositions of all hematologic malignancies, yet the genetic basis for these differences is not clearly defined. The highly polymorphic HLA genes of the major histocompatibility complex play a central role...
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