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Article

Identification of a Graft Versus Host Disease-Associated Human Minor Histocompatibility Antigen

9 Jun 1995

Abstract excerpt

Minor histocompatibility antigen disparities between human leukocyte antigen (HLA)-matched bone marrow donors and recipients are a major risk factor for graft versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that recognized the minor histocompatibility antigen HA-2 was previously isolated from a patient with severe GVHD after HLA-identical bone marrow transplantation. The HLA-A2.1-bound...

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Identifiers

PMID: 7539551
DOI: 10.1126/science.7539551

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Identification of a Graft Versus Host Disease-Associated Human Minor Histocompatibility AntigenPMID 7539551Read ↗

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Correlation between disparity for the minor histocompatibility antigen HA-1 and the development of acute graft-versus-host disease after allogeneic marrow transplantation.Semantic proximity Read ↗

Disparity for a newly identified minor histocompatibility antigen, HA‐8, correlates with acute graft‐<i>versus</i>‐host disease after haematopoietic stem cell transplantation from an HLA‐identical siblingSemantic proximity Read ↗

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High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations.Semantic proximity Read ↗

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