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Article

Optimized Whole Genome Association Scanning for Discovery of HLA Class I-Restricted Minor Histocompatibility Antigens.

Frontiers in immunology - 1 Jan 2020

Fuchs Kyra J, Honders M Willy, van der Meijden Edith D, Adriaans Alwin E, van der Lee Dyantha I, Pont Margot J, Monajemi Ramin, Kielbasa Szymon M, 't Hoen Peter A C, van Bergen Cornelis A M, Falkenburg J H Frederik, Griffioen Marieke

Abstract excerpt

Patients undergoing allogeneic stem cell transplantation as treatment for hematological diseases face the risk of Graft-versus-Host Disease as well as relapse. Graft-versus-Host Disease and the favorable Graft-versus-Leukemia effect are mediated by donor T cells recognizing polymorphic peptides, which are presented on the cell surface by HLA molecules and result from single nucleotide polymorphism alleles that...

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Identifiers

PMID: 32362897
DOI: 10.3389/fimmu.2020.00659
PMCID: PMC7180171

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