Article
A transforming growth factorbeta1 signal peptide variant increases secretion in vitro and is associated with increased incidence of invasive breast cancer.
Cancer research - 15 May 2003
Dunning Alison M, Ellis Peter D, McBride Simon, Kirschenlohr Heidi L, Healey Catherine S, Kemp Paul R, Luben Robert N, Chang-Claude Jenny, Mannermaa Arto, Kataja Vesa, Pharoah Paul D P, Easton Douglas F, Ponder Bruce A J, Metcalfe James C
Abstract excerpt
There is evidence that transforming growth factor (TGF)beta acts as a suppressor of tumor initiation but also as a promoter of tumor progression when the antiproliferative effect of the TGFbeta signaling pathway has been overridden by other oncogenic mutations. Several somatic mutations that disrupt the TGFbeta-SMAD signaling pathway have been reported in human breast tumors. We have examined the association...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.