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Article

Combined genetic assessment of transforming growth factor-beta signaling pathway variants may predict breast cancer risk.

Cancer research - 15 Apr 2005

Kaklamani Virginia G, Baddi Lisa, Liu Junjian, Rosman Diana, Phukan Sharbani, Bradley Ciarán, Hegarty Chris, McDaniel Bree, Rademaker Alfred, Oddoux Carole, Ostrer Harry, Michel Loren S, Huang Helen, Chen Yu, Ahsan Habibul, Offit Kenneth, Pasche Boris

Abstract excerpt

There is growing evidence that common variants of the transforming growth factor-beta (TGF-beta) signaling pathway may modify breast cancer risk. In vitro studies have shown that some variants increase TGF-beta signaling, whereas others have an opposite effect. We tested the hypothesis that a combined genetic assessment of two well-characterized variants may predict breast cancer risk. Consecutive patients (n =...

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Source

Identifiers

PMID: 15833881
DOI: 10.1158/0008-5472.CAN-04-2961

Genes

TGFBR1
TGFB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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