Article
Strong impact of TGF-β1 gene polymorphisms on breast cancer risk in Indian women: a case-control and population-based study.
PloS one - 1 Jan 2013
Pooja Singh, Francis Amirtharaj, Rajender Singh, Tamang Rakesh, Rajkumar Raja, Saini Karan Singh, Megu Kaling, Goel Madhu Mati, Surekha Daminani, Rao Digumarthi Raghunatha, Rao Lakshmi, Ramachandra Lingadakai, Kumar Sandeep, Kumar Surender, Vishnupriya Satti, Satyamoorthy Kapaettu, Negi Mahendra Pal Singh, Thangaraj Kumarasamy, Konwar Rituraj
Abstract excerpt
INTRODUCTION: TGF-β1 is a multi-functional cytokine that plays an important role in breast carcinogenesis. Critical role of TGF-β1 signaling in breast cancer progression is well documented. Some TGF-β1 polymorphisms influence its expression; however, their impact on breast cancer risk is not clear. METHODS: We analyzed 1222 samples in a candidate gene-based genetic association study on two distantly located and...
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