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Article

Int7G24A variant of transforming growth factor-beta receptor type I is associated with invasive breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jan 2006

Chen Taiping, Jackson Chad R, Link Andrew, Markey Michael P, Colligan Bruce M, Douglass Larry E, Pemberton Jackson O, Deddens James A, Graff Jeremy R, Carter Julia H

Abstract excerpt

PURPOSE: The transforming growth factor-beta (TGF-beta) signaling pathway has been frequently implicated in breast cancer. An intronic variant (Int7G24A) of TGF-beta receptor type I (TGFBR1) is associated with kidney and bladder cancers in our recent study. We hypothesize that this germline variant may be involved in development and progression of breast cancer. EXPERIMENTAL DESIGN: Case-control studies were...

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Share to Activin Receptors, Type I
Share to Carcinoma, Ductal, Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Lobular

Share to Germ-Line Mutation

Share to Neoplasm Invasiveness

Share to Polymorphism, Single-Stranded Conformational

Share to Receptor, Transforming Growth Factor-beta Type I

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Source

Identifiers

PMID: 16428477
DOI: 10.1158/1078-0432.CCR-05-1518

Genes

TGFBR1

Provenance

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