Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel functional polymorphism in the transforming growth factor-beta2 gene promoter and tumor progression in breast cancer.

Cancer research - 1 Aug 2006

Beisner Julia, Buck Miriam B, Fritz Peter, Dippon Jürgen, Schwab Matthias, Brauch Hiltrud, Zugmaier Gerhard, Pfizenmaier Klaus, Knabbe Cornelius

Abstract excerpt

Transforming growth factor-beta (TGF-beta), a multifunctional growth factor, plays an important role in breast cancer. There is increasing evidence that enhanced expression of TGF-beta promotes breast cancer progression contributing to metastasis and invasiveness of the tumor. We identified a functional polymorphism in the TGFB2 promoter, a 4-bp insertion at position -246 relative to the transcriptional start...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Promoter Regions, Genetic

Share to Sp1 Transcription Factor

Share to Transcriptional Activation

Share to Transforming Growth Factor beta

Share to Transforming Growth Factor beta2

Source

Identifiers

PMID: 16885354
DOI: 10.1158/0008-5472.CAN-06-0634

Genes

TGFB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel functional polymorphism in the transforming growth factor-beta2 gene promoter and tumor progression in breast cancer.PMID 16885354Read ↗

Allelic diversity in the TGFB1 regulatory region: characterization of novel functional single nucleotide polymorphisms.Semantic proximity Read ↗

TGF-β1 functional polymorphisms: a review.Semantic proximity Read ↗

Functional impact of sequence variation in the promoter region of TGFB1.Semantic proximity Read ↗

Higher stromal expression of transforming growth factor-beta type II receptors is associated with poorer prognosis breast tumors.Semantic proximity Read ↗

TGFBR1*6A as a modifier of breast cancer risk and progression: advances and future prospectsSemantic proximity Read ↗

Bioinformatic and functional analysis of TGFBR1 polymorphisms.Semantic proximity Read ↗

Novel alleles of the transforming growth factor β-1 regulatory region and exon 1.Semantic proximity Read ↗

Effect of functional variant rs11466313 on breast cancer susceptibility and TGFB1 promoter activity.Semantic proximity Read ↗

TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study.Semantic proximity Read ↗

Genetic polymorphisms of TGF-beta1 & TNF-beta and breast cancer risk.Semantic proximity Read ↗

Strong impact of TGF-β1 gene polymorphisms on breast cancer risk in Indian women: a case-control and population-based study.Semantic proximity Read ↗

Novel functional single nucleotide polymorphisms in the latent transforming growth factor-beta binding protein-1L promoter: effect on latent transforming growth factor-beta binding protein-1L expression level and possible prognostic significance in ovarian cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.